Abacavir Lamivudine: Mechanism of action
-
Abacavir Lamivudine combination medicine is used by healthcare professionals to treat human immunodeficiency virus type 1 infection. This combination of medicine comes in 600 mg and 300 mg tablets for oral administration. The active ingredients in the tablets are Abacavir and Lamivudine. Cellular enzymes convert abacavir to the active metabolite, carbovir triphosphate (CBV-TP). CBV-TP inhibits the activity of HIV-1 reverse transcriptase (RT) by competing with the natural substrate dGTP and its incorporation into viral DNA. And Lamivudine is phosphorylated to its active 5′-triphosphate metabolite, Lamivudine triphosphate (3TC-TP). The principal mode of action of Lamivudine triphosphate is inhibition of RT through DNA chain termination after incorporation of the nucleotide analogue.
Abacavir Lamivudine price from India is reasonable, and one can find this combination medicine with certified generic medicine suppliers.